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KMID : 0377619720230020177
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Korean Jungang Medical Journal
1972 Volume.23 No. 2 p.177 ~ p.184
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Effect of Artificial Pneumothorax on the Pulmonary Surfactant in the Rabbit
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Abstract
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In order to observe a possible effect of artificial pneumothorax and the process of spontaneous recovery on the activities of pulmonary surfactant, the rabbit was subjected to artificial pneumothorax by means of puncture of the chest wall with needle, and the lung extract was prepared at 4, 6, 24 and 36 hours after the pneumothorax was produced. The tension-area diagram of the lung extract was recorded automatically using the modified Langmuir-Wilhelmy balance with a synchronized recording system, and the compa-ison was made with the normal. Also, the P-A X-ray film of the rabbit chest was taken at each experimental hour in order to observe the degree of spontaneous absorption of air through the chest wall.
The results thus obtained are summarized as follows;
1) The maximal surface tension, minimal surface tension, width of the tensionarea diagram at the surface area of 40% and stability index of the normal lung extract was 37.8±2.1 dynes/cm, 6.6±2.1 dynes/cm, 28.0±2.9 dynes/cm and 1. 17±0.28, respectively.
2) The surface tensions and stability index of the control group where the lung extract was prepared immediately following the artificial pneumothorax, did not show any significant difference from the normal.
3) The maximal and minimal surface tensions were elevated at 4 hours and continued to be so up to 36 hours after the artificial pneumothorax, but a decline of the surface tensions were observed at 48 experimental hours.
4) The stability index and the width of the tension-area diagram was lower than the normal throughout the entire experimental hours with the lowest values at 36 hours after the artificial pneumothorax.
5) A greate deal of the air injected into the thoracic cavity was absorbed through the chest wall between 24 and 36 hours after the air injection, and the absorption of the air was greatest at 48 hours.
6) Fromm the above, the artificial surface pneumothorax is concluded to decrease the tensions, and the spontaneous absorption of the injected air tends to bring the pulmonary surfactant activity to the normal.
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